Investigating how RNA modifications affect cancer caused by RAS mutations
Official title: RNA oxidation in RAS-driven cancer
Funded at Rowan University School/osteopathic Med · NIH-10951216 · Data updated 2026-11-12
This study is looking at how certain chemical changes in RNA, caused by harmful molecules in the body, affect gene activity in non-small cell lung cancer patients with RAS mutations, with the hope of finding new ways to understand and treat this type of cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University School/osteopathic Med NIH-funded |
| Lab location | 1 site (Stratford, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $396,654 |
| NIH project number | 1R21CA293416-01 |
| Project ID | NIH-10951216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with RAS mutations.
✕Less likely to help
Patients with other types of lung cancer or those without RAS mutations may not benefit from this research.
What this research studies
This research explores the role of chemical modifications in RNA, specifically how reactive oxidative species (ROS) influence gene expression in non-small cell lung cancer (NSCLC) driven by RAS mutations. The study aims to identify patterns of oxidative modifications in RNA and understand the molecular mechanisms that interpret these changes. By utilizing advanced sequencing and biochemical techniques, the research seeks to uncover how these modifications impact cancer cell behavior and gene regulation. This could lead to new insights into cancer biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating non-small cell lung cancer by targeting RNA modifications.
How similar studies have gone: While the specific focus on RNA oxidation in RAS-driven cancer is relatively novel, similar approaches have shown promise in understanding cancer biology.
Where this research is happening
-
Rowan University School/osteopathic Med
Stratford, United States Active
Researchers
- Principal investigator: Pestov, Dimitri G — Rowan University School/osteopathic Med
- Study coordinator: Pestov, Dimitri G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.