Investigating how RNA modifications affect Alzheimer's disease progression
Official title: Role of R-loops in transcriptional stress, genome instability, and chronic immune response in Alzheimer's disease
Funded at Purdue University · NIH-10933512 · Data updated 2026-11-12
This study is looking at how certain changes in RNA might play a part in the development of Alzheimer's disease, using fruit flies to see how these changes can cause problems in our cells and possibly lead to new treatments for the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $472,642 |
| NIH project number | 5R01NS135611-02 |
| Project ID | NIH-10933512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients with early-onset Alzheimer's disease or those with non-age-related forms of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific RNA modifications in the development of Alzheimer's disease (AD), particularly how these modifications can lead to genome instability and chronic immune responses. By using a Drosophila model of AD, the researchers will explore how disruptions in RNA structures, known as R-loops, contribute to the disease's progression. The study aims to identify the mechanisms by which these RNA alterations affect cellular processes and may lead to new therapeutic strategies for AD.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that address the underlying causes of Alzheimer's disease rather than just alleviating symptoms.
How similar studies have gone: Previous research has shown promising results in targeting RNA modifications for therapeutic purposes in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Hall, Hana — Purdue University
- Study coordinator: Hall, Hana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.