Investigating how RNA modifications affect Alzheimer's disease
Official title: Role of Mettl3-dependent RNA m6A dysregulation in Alzheimer's disease
Funded at Case Western Reserve University · NIH-10739065 · Data updated 2026-11-12
This study is looking at how a special change in RNA might affect the brain in people with Alzheimer's disease, hoping to find new ways to help improve symptoms and slow down memory loss.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,156,262 |
| NIH project number | 1RF1AG083811-01 |
| Project ID | NIH-10739065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk due to genetic or environmental factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the role of a specific RNA modification, known as m6A, in the development of Alzheimer's disease (AD). It aims to understand how changes in gene expression related to this modification contribute to cognitive decline and neurodegeneration in AD patients. By studying the effects of METTL3, an enzyme involved in m6A modification, the research seeks to uncover potential mechanisms that lead to Alzheimer's symptoms. Patients may benefit from insights that could lead to new therapeutic strategies targeting these molecular pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results regarding the role of RNA modifications in neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Zhu, Xiongwei — Case Western Reserve University
- Study coordinator: Zhu, Xiongwei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.