Investigating how RNA methylation affects heart failure progression
Official title: RNA methylation in the progress of heart failure
Funded at University of Alabama at Birmingham · NIH-11046853 · Data updated 2026-11-12
This study is looking at how changes to certain RNA molecules might affect heart health, especially in people with heart failure, to find new ways to help manage or prevent this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | March 5, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $561,392 |
| NIH project number | 1R01HL173677-01A1 |
| Project ID | NIH-11046853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults experiencing cardiac dysfunction or those at risk of developing heart failure.
✕Less likely to help
Patients with heart failure due to non-cardiac causes or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA methylation in cardiac fibrosis, a key factor in heart failure. It aims to explore how the modification of specific RNA molecules can influence the stability and function of genes involved in heart tissue repair and remodeling. By examining the molecular mechanisms that regulate the translocation of β-catenin, a protein linked to fibrosis, the study seeks to uncover new therapeutic targets for treating heart failure. Patients may benefit from insights gained into how to better manage or prevent heart failure through targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of heart failure.
How similar studies have gone: Other research has shown promising results in understanding RNA modifications in various diseases, suggesting potential for success in this area as well.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Verma, Suresh K — University of Alabama at Birmingham
- Study coordinator: Verma, Suresh K
Related research
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AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
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Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
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Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.