Investigating how RNA influences the movement of neural crest cells
Official title: RNA localization in neural crest migratory protrusions
Funded at University of Minnesota · NIH-11056952 · Data updated 2026-11-12
This study is looking at how certain cells in the body, called neural crest cells, move and develop properly, which is important for preventing birth defects like Treacher-Collins syndrome and DiGeorge syndrome, and it aims to find out how specific molecules help guide these cells during their journey.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 16, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $444,808 |
| NIH project number | 1R21DE033800-01A1 |
| Project ID | NIH-11056952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by congenital birth defects related to neural crest development, such as Treacher-Collins syndrome or DiGeorge syndrome.
✕Less likely to help
Patients with conditions unrelated to neural crest cell migration or those who do not have congenital birth defects may not benefit from this research.
What this research studies
This research explores the mechanisms behind the migration of neural crest cells (NCCs), which are crucial for proper development and can lead to various congenital birth defects when they malfunction. The study focuses on understanding how specific RNAs are localized within the protrusions of these cells, which may be essential for their directed movement and differentiation. By analyzing the RNA and protein composition of NCC projections, the researchers aim to uncover the cellular processes that guide these cells during development. This knowledge could provide insights into conditions like Treacher-Collins syndrome and DiGeorge syndrome, potentially leading to better therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital birth defects associated with neural crest cell migration.
How similar studies have gone: Other research has shown success in understanding cellular migration mechanisms, but this specific approach focusing on RNA localization in NCCs is relatively novel.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Artinger, Kristin — University of Minnesota
- Study coordinator: Artinger, Kristin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.