Investigating how RNA influences a key protein complex involved in gene regulation and cancer.
Biophysical interrogation of the RNA-mediated mechanisms regulating Polycomb Repressive Complex 2 activity
This study is looking at how RNA helps control a protein complex called PRC2, which is important for turning genes on and off during development and cancer, to better understand how these processes work and how they might be affected in cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-10915571 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNA in regulating the Polycomb Repressive Complex 2 (PRC2), a protein complex essential for gene silencing during development and cancer. The study aims to clarify how PRC2 interacts with RNA and how these interactions affect its ability to bind to DNA and regulate gene expression. By employing advanced biophysical techniques, the research will explore the mechanisms by which RNA can both promote and inhibit PRC2's activity. This could provide insights into the fundamental processes of gene regulation and the development of cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by epigenetic changes, particularly those involving PRC2.
Not a fit: Patients with conditions unrelated to epigenetic regulation or those not affected by PRC2 activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers by targeting the mechanisms of gene regulation.
How similar studies have performed: Previous studies have shown promising results in understanding RNA's role in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Hemphill, Wayne Oliver — University of Colorado
- Study coordinator: Hemphill, Wayne Oliver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.