Investigating how RNA in small vesicles affects inflammation in obesity
Official title: RNA silencing machinery in extracellular vesicle-mediated immunometabolic regulation
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11001229 · Data updated 2026-11-12
This study is looking at tiny particles in the body that carry RNA and how they might play a role in the inflammation caused by obesity, which can lead to health issues like type 2 diabetes, to help find better ways to manage obesity and its related problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $588,775 |
| NIH project number | 5R01DK134646-02 |
| Project ID | NIH-11001229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents and adults who are obese or at risk for obesity-related conditions.
✕Less likely to help
Patients who are not obese or do not have obesity-related inflammatory conditions may not benefit from this research.
What this research studies
This research explores the role of small extracellular vesicles (sEVs) that carry RNA, particularly microRNA, in the inflammation associated with obesity. By examining how these vesicles influence both the cells that release them and those that receive them, the study aims to uncover the mechanisms behind obesity-related inflammation and its connection to chronic diseases like type 2 diabetes. The research involves analyzing RNA profiles in these vesicles and their effects on cellular functions, which could lead to new insights into managing obesity and its complications.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity-related inflammation and metabolic diseases.
How similar studies have gone: Other research has shown promising results in understanding the role of extracellular vesicles in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Nakamura, Takahisa — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Nakamura, Takahisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.