Investigating how RNA editing affects blood vessel cells in pulmonary hypertension
Official title: RNA editing controls pulmonary endothelial pathophenotypes in pulmonary hypertension
Funded at National Jewish Health · NIH-11139790 · Data updated 2026-11-12
This study is looking at how a special enzyme called ADAR1 affects the health of cells in the lungs that help keep blood flowing properly, with the goal of finding new ways to improve treatments for people with pulmonary hypertension.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL161320-03 |
| Project ID | NIH-11139790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary hypertension, particularly those experiencing early apoptosis in their pulmonary artery endothelial cells.
✕Less likely to help
Patients with pulmonary hypertension caused by factors unrelated to RNA editing or those with advanced disease stages may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA editing in pulmonary hypertension, a severe condition affecting blood vessels in the lungs. The study aims to explore how a specific enzyme, ADAR1, influences the survival of pulmonary artery endothelial cells, which are crucial for maintaining healthy blood flow. By examining the genetic changes caused by RNA editing, researchers hope to uncover new insights into the mechanisms driving this disease and identify potential therapeutic targets. Patients may benefit from advancements in treatment options that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for pulmonary hypertension, improving patient outcomes.
How similar studies have gone: While the specific role of ADAR1 in pulmonary vascular function is not well-studied, similar approaches in RNA editing have shown promise in other areas of vascular research.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Woodcock, Chen-Shan Julia — National Jewish Health
- Study coordinator: Woodcock, Chen-Shan Julia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.