Investigating how RNA decay affects triple-negative breast cancer
Novel Triple-Negative Breast cancer vulnerability governed by PNPT1-mediated RNA decay
['FUNDING_FELLOWSHIP'] · BAYLOR COLLEGE OF MEDICINE · NIH-10974461
This study is looking at how a certain enzyme called PNPT1 affects triple-negative breast cancer cells, and by turning it off, researchers hope to find new ways to make these tough cancer cells die, which could lead to better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10974461 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the vulnerabilities of triple-negative breast cancer (TNBC), a particularly aggressive form of breast cancer with few treatment options. The study examines the role of a specific enzyme, PNPT1, in the decay of RNA, which is crucial for regulating gene expression. By silencing PNPT1 in cancer cells that have hyperactivated the MYC gene, researchers aim to induce cell stress and death, potentially leading to new therapeutic strategies. Patients may benefit from insights that could lead to more effective treatments for TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer, particularly those with MYC hyperactivation.
Not a fit: Patients with other subtypes of breast cancer or those without MYC hyperactivation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with triple-negative breast cancer.
How similar studies have performed: While the specific approach of targeting RNA decay in TNBC is novel, previous research has shown that targeting RNA metabolism can be effective in other cancer types.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, ANDREW — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: YANG, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell, Breast Cancer cell line, Cancer Cause, Cancer Etiology