Investigating how RNA changes in Powassan virus affect its behavior and spread
The role of RNA deletion and duplication events in Powassan virus pathogenesis and evolution
This study is looking at how changes in the RNA of the Powassan virus, which is carried by ticks, affect how the virus makes people sick and avoids the immune system, helping us learn more about tick-borne illnesses and their effects on health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10795083 on NIH RePORTER |
What this research studies
This research focuses on understanding how deletions and duplications in the RNA of the Powassan virus influence its ability to cause disease and evade the immune system. By analyzing RNA samples collected from ticks that carry the virus, researchers aim to map specific genetic changes and their implications for the virus's lifecycle. The study employs advanced laboratory techniques to detect these RNA alterations, which could provide insights into how the virus evolves and spreads. Ultimately, this research seeks to enhance our understanding of tick-borne viral infections and their impact on human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Powassan virus infection or are at high risk of exposure to infected ticks.
Not a fit: Patients who are not affected by tick-borne viruses or do not reside in areas where Powassan virus is prevalent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating Powassan virus infections.
How similar studies have performed: Previous research on other RNA viruses has shown that understanding genetic recombination can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Piantadosi, Anne L — Emory University
- Study coordinator: Piantadosi, Anne L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.