Investigating how RNA changes contribute to cancer development
The role and mechanism of alternative RNA splice variants and gene fusions as drivers of cancer
This study is looking at how certain genetic changes in cancer can help us understand the disease better, which could lead to more personalized treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11063603 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of alternative RNA splice variants and gene fusions in driving cancer. By examining how these genetic changes occur, the study aims to uncover the mechanisms that lead to malignancies. Patients may benefit from insights gained into their specific cancer types, potentially leading to more targeted therapies. The research employs advanced genetic analysis techniques to identify and characterize these RNA alterations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with various types of cancer, particularly those with known RNA splice variants or gene fusions.
Not a fit: Patients with cancers that do not involve alternative RNA splicing or gene fusions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for cancer patients.
How similar studies have performed: Other research has shown promising results in understanding the role of RNA alterations in cancer, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Holland, Eric C. — Fred Hutchinson Cancer Center
- Study coordinator: Holland, Eric C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.