Investigating how RNA caps affect gene expression and stability
Official title: 5’ end RNA Caps in Gene Expression
Funded at Rutgers, the State Univ of N.j. · NIH-11080376 · Data updated 2026-11-12
This study is looking at how different types of RNA caps affect the way genes work and how long they last, which could help us find new ways to treat diseases related to gene expression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $659,767 |
| NIH project number | 5R35GM149262-03 |
| Project ID | NIH-11080376 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases where gene expression plays a critical role.
✕Less likely to help
Patients with conditions unrelated to RNA metabolism or gene expression may not benefit from this research.
What this research studies
This research focuses on understanding the role of both traditional and new types of RNA caps in regulating gene expression and RNA stability. By examining how these caps influence the lifespan and functionality of messenger RNA (mRNA), the study aims to uncover the mechanisms that control gene activity. The research involves detailed biochemical analyses to identify and characterize these RNA caps, which could lead to insights into how changes in RNA stability can impact health and disease. Patients may benefit from this research as it could reveal new targets for therapies aimed at diseases linked to gene expression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by dysregulation of gene expression.
How similar studies have gone: While the investigation of RNA caps is a relatively novel area, previous studies have shown promising results in understanding RNA stability and its implications for gene expression.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Kiledjian, Megerditch — Rutgers, the State Univ of N.j.
- Study coordinator: Kiledjian, Megerditch
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.