Investigating how RNA binding proteins influence neuron activity and growth
How dynamic interactions of RNA binding proteins control activity-dependent translation in neurons
This study is looking at how certain proteins in brain cells help move and use RNA, which is important for how these cells grow and communicate, and it aims to find out how these proteins work together to keep our brains healthy and functioning well.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004119 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNA binding proteins (RBPs) in the transport and translation of RNA within neurons, which is essential for processes like axonal growth and synaptic plasticity. The study aims to explore how these proteins interact with RNA molecules and each other, forming complex networks that regulate neuronal functions. By employing a novel network perspective, the research seeks to uncover the dynamic interactions of RBPs and their impact on neuronal activity, potentially leading to new insights into brain function and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders that affect neuronal function and plasticity.
Not a fit: Patients with non-neurological conditions or those whose neurological issues are unrelated to RNA binding protein functions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological conditions by enhancing our understanding of neuronal growth and plasticity.
How similar studies have performed: While the specific approach of studying RBP interactions in a network context is novel, previous research has shown success in understanding RNA dynamics in neuronal biology.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Doron-Mandel, Ella — Columbia Univ New York Morningside
- Study coordinator: Doron-Mandel, Ella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.