Investigating how RNA binding proteins influence neuron activity and growth
Official title: How dynamic interactions of RNA binding proteins control activity-dependent translation in neurons
Funded at Columbia Univ New York Morningside · NIH-11004119 · Data updated 2026-11-12
This study is looking at how certain proteins in brain cells help move and use RNA, which is important for how these cells grow and communicate, and it aims to find out how these proteins work together to keep our brains healthy and functioning well.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $123,192 |
| NIH project number | 5K99NS135103-02 |
| Project ID | NIH-11004119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological disorders that affect neuronal function and plasticity.
✕Less likely to help
Patients with non-neurological conditions or those whose neurological issues are unrelated to RNA binding protein functions may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA binding proteins (RBPs) in the transport and translation of RNA within neurons, which is essential for processes like axonal growth and synaptic plasticity. The study aims to explore how these proteins interact with RNA molecules and each other, forming complex networks that regulate neuronal functions. By employing a novel network perspective, the research seeks to uncover the dynamic interactions of RBPs and their impact on neuronal activity, potentially leading to new insights into brain function and development.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological conditions by enhancing our understanding of neuronal growth and plasticity.
How similar studies have gone: While the specific approach of studying RBP interactions in a network context is novel, previous research has shown success in understanding RNA dynamics in neuronal biology.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Doron-Mandel, Ella — Columbia Univ New York Morningside
- Study coordinator: Doron-Mandel, Ella
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.