Investigating how RNA Binding Proteins influence gene expression changes
Official title: How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changes
Funded at Columbia Univ New York Morningside · NIH-10765255 · Data updated 2026-11-12
This study is looking at how certain proteins that bind to RNA help control how genes work, which is important for understanding how our cells develop and function, and it could help us learn more about diseases too.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $551,324 |
| NIH project number | 1R35GM152258-01 |
| Project ID | NIH-10765255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene expression changes, such as certain neurological disorders or cancers.
✕Less likely to help
Patients with conditions unrelated to gene expression or those not affected by RNA Binding Protein interactions may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA Binding Proteins (RBPs) in regulating gene expression. By examining how these proteins interact with RNA and each other, the study aims to uncover the complex networks that control various biological processes, including cell development and function. The researchers will employ advanced methods to measure the interactions of multiple RBPs simultaneously, providing insights into their regulatory mechanisms during both normal and disease states.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene expression dysregulation.
How similar studies have gone: Previous research has shown promising results in understanding the roles of RBPs in gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Jovanovic, Marko — Columbia Univ New York Morningside
- Study coordinator: Jovanovic, Marko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.