Investigating how RNA binding proteins affect kidney inflammation in autoimmune diseases
RNA binding proteins in end-organ autoimmune pathology
This study is looking at how certain proteins in our cells might affect kidney inflammation caused by autoimmune diseases like ANCA vasculitis and Goodpasture disease, with the hope of finding new ways to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11005394 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNA binding proteins in the inflammation of the kidneys caused by autoimmune diseases, particularly conditions like ANCA vasculitis and Goodpasture disease. It explores how IL-17, a cytokine involved in immune responses, contributes to kidney damage through the dysregulation of T helper cells and the production of antibodies. By identifying specific RNA binding proteins that influence IL-17 signaling, the research aims to uncover potential therapeutic targets that could help mitigate kidney inflammation and damage in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune conditions that cause kidney inflammation, such as ANCA vasculitis or Goodpasture disease.
Not a fit: Patients with kidney diseases not related to autoimmune processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce kidney inflammation and improve outcomes for patients with autoimmune kidney diseases.
How similar studies have performed: Previous research has shown promising results in targeting IL-17 signaling pathways in autoimmune diseases, indicating that this approach may be effective.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Gaffen, Sarah L — University of Pittsburgh at Pittsburgh
- Study coordinator: Gaffen, Sarah L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.