Investigating how RNA-binding proteins affect gene expression and cancer development
Official title: High-Throughput Measurements of RNA-Mediated Regulation of Gene Expression and Oncogenesis
Funded at Stanford University · NIH-11059592 · Data updated 2026-11-12
This study is looking at how certain proteins that bind to RNA might affect gene activity and contribute to cancer, with the goal of finding new ways to understand and treat the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,224 |
| NIH project number | 5F30CA287739-02 |
| Project ID | NIH-11059592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that have been linked to mutations in RNA-binding proteins.
✕Less likely to help
Patients with cancers unrelated to RNA-binding protein dysregulation may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA-binding proteins (RBPs) in regulating gene expression and their implications for cancer. By examining how RBPs interact with RNA processing machinery, the project aims to uncover how disruptions in these interactions can lead to cancerous changes in cells. The approach involves high-throughput measurements to systematically analyze the functions of various RBPs and their domains, which could provide insights into cancer progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for predicting and treating cancers associated with RNA-binding protein mutations.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA-binding proteins in cancer, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Thurm, Abby — Stanford University
- Study coordinator: Thurm, Abby
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.