Investigating how RNA-binding proteins affect ALS and other neurodegenerative diseases
Exploring functional complexes and disease networks within human RNA-binding protein interactomes
This study is looking at how certain proteins that bind to RNA might affect the way our cells work, especially in relation to neurodegenerative diseases like ALS, with the hope that understanding these processes could help develop new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10879161 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNA-binding proteins (RBPs) in the regulation of RNA metabolism, which is crucial for cellular function. By examining how these proteins interact with RNA and each other, the study aims to uncover the molecular mechanisms that contribute to neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS). The research employs advanced computational methods to classify RBPs and explore their biological functions, particularly in relation to disease-associated proteins. Patients may benefit from insights that could lead to new therapeutic strategies targeting RNA metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis or related neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those without a diagnosis of ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with ALS and similar neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding RNA-binding proteins in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Brannan, Kristopher — Methodist Hospital Research Institute
- Study coordinator: Brannan, Kristopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.