Investigating how RNA affects coenzyme activity
Official title: RNA-coupled Coenzymes
Funded at University of Wisconsin Milwaukee · NIH-10359222 · Data updated 2026-11-12
This study is looking at how a special molecule called RNA can change the way another important molecule, NAD, works in our bodies, which could help us understand more about how our metabolism functions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin Milwaukee NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 20, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $442,896 |
| NIH project number | 1R15GM144859-01 |
| Project ID | NIH-10359222 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with metabolic disorders such as diabetes or fatty liver disease.
✕Less likely to help
Patients with conditions unrelated to metabolic regulation or those not affected by NAD-related pathways may not benefit from this research.
What this research studies
This research explores the role of nicotinamide adenine dinucleotide (NAD), a crucial coenzyme involved in biological reactions, particularly how RNA influences its activity. The study hypothesizes that the RNA component can modulate the function of NAD-utilizing enzymes, potentially affecting the rates of biochemical reactions. By comparing the effectiveness of various enzymes using different forms of NAD-capped RNA, the research aims to uncover new insights into the interaction between RNA and coenzymes. This could lead to a better understanding of metabolic processes and their regulation.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of metabolic regulation and lead to new therapeutic strategies for conditions like diabetes and liver diseases.
How similar studies have gone: While the role of NAD in metabolism is well-established, the specific interaction between RNA and coenzyme activity is a novel area of investigation with limited prior research.
Where this research is happening
-
University of Wisconsin Milwaukee
Milwaukee, United States Active
Researchers
- Principal investigator: Frick, David N — University of Wisconsin Milwaukee
- Study coordinator: Frick, David N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.