Investigating how RNA affects blood vessel health in diabetes
Official title: RNA-mediated endotheliopathy in diabetic vasculopathy
Funded at Beckman Research Institute/city of Hope · NIH-10789614 · Data updated 2026-11-12
This study is looking at how certain RNA molecules might be causing problems in the blood vessels of people with diabetes, and it hopes to find new ways to help improve their blood vessel health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2031 |
| Funding year | 2024 |
| Award (this year) | $543,268 |
| NIH project number | 1R35HL171550-01 |
| Project ID | NIH-10789614 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with diabetes mellitus who are experiencing or at risk for diabetic vasculopathy.
✕Less likely to help
Patients without diabetes or those who do not have vascular complications related to diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA in the dysfunction of endothelial cells, which are crucial for blood vessel health, particularly in individuals with diabetes. The study aims to identify the epigenetic factors that contribute to vascular damage in diabetic patients and explore potential RNA-based therapies to improve vascular function. By examining the effects of long non-coding RNAs and other RNA molecules, the research seeks to uncover new treatment strategies for diabetic vasculopathy, a common complication of diabetes. Patients may benefit from insights that could lead to innovative therapies targeting the underlying causes of their vascular issues.
Why it matters
Potential benefit: If successful, this research could lead to new RNA-based therapies that improve blood vessel function and reduce complications in diabetic patients.
How similar studies have gone: Previous research has shown promising results in targeting RNA mechanisms for vascular health, indicating potential for success in this novel approach.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Chen, Zhen Bouman — Beckman Research Institute/city of Hope
- Study coordinator: Chen, Zhen Bouman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.