Investigating how risedronate can prevent bone loss after bariatric surgery
Adding bone microarchitecture and strength measures to the STRONG BONES randomized trial examining risedronate use to mitigate bone loss after bariatric surgery
['FUNDING_R01'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-11038003
This study is looking at whether the medication risedronate can help prevent bone loss in people over 40 who have had sleeve gastrectomy for weight loss, and it will involve 120 participants taking either the medication or a placebo for six months.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-11038003 on ClinicalTrials.gov |
What this research studies
This research focuses on patients who have undergone bariatric surgery, specifically sleeve gastrectomy, which can lead to bone loss. It aims to determine if the medication risedronate, typically used for osteoporosis, can help mitigate this bone loss. The study will involve 120 participants aged 40 and older, who will be randomly assigned to receive either risedronate or a placebo for six months. Researchers will use advanced imaging techniques to assess changes in bone microarchitecture and strength over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 40 and older who have recently undergone sleeve gastrectomy.
Not a fit: Patients who have not had bariatric surgery or are younger than 40 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help prevent bone fragility in patients who have undergone bariatric surgery, improving their overall health and quality of life.
How similar studies have performed: Previous studies have shown that bisphosphonates can be effective in preventing bone loss in various populations, suggesting potential success for this approach in bariatric surgery patients.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEAVER, ASHLEY — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: WEAVER, ASHLEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.