Investigating how ribosomal proteins and their pseudogenes respond to stress in neurons
The neurobiology of ribosomal proteins and ribosomal-protein-pseudogenes
This study is looking at how stress affects certain proteins in brain cells, using mice to see if changes in these proteins can help us understand how stress impacts brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project ID | NIH-11159126 on NIH RePORTER |
What this research studies
This research explores the role of ribosomal proteins and their pseudogenes in the stress response of neurons. Using mouse models, the study examines how chronic stress affects the expression of these proteins and their pseudogenes, potentially altering ribosome composition in neurons. The researchers will employ advanced techniques such as proteomics and RNA sequencing to analyze these changes and their implications for neuronal function. By understanding these mechanisms, the research aims to shed light on the neurobiological impacts of stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic stress or related neurological conditions.
Not a fit: Patients who do not have stress-related neurological conditions or who are not experiencing chronic stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how stress affects brain function and may inform future treatments for stress-related neurological conditions.
How similar studies have performed: While the specific focus on ribosomal protein pseudogenes in stress response is relatively novel, similar studies have shown promising results in understanding the role of ribosomal proteins in various biological processes.
Where this research is happening
Laramie, United States
- University of Wyoming — Laramie, United States (Active)
Researchers
- Principal investigator: Shukla, Rammohan — University of Wyoming
- Study coordinator: Shukla, Rammohan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.