Investigating how Rho-kinase signaling affects energy balance and body weight regulation
Rho-kinase signaling in energy balance
This study is looking at how a specific signaling pathway in the body affects weight and energy balance, which could help us understand obesity better and find new ways to manage it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11092688 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Rho-kinase signaling in the melanocortin pathway, which is crucial for maintaining body weight and energy balance. By studying the melanocortin-4 receptor (MC4R) and its interactions with Rho-kinase (ROCK1), the research aims to uncover how these mechanisms influence food intake and energy expenditure. The study will involve both animal models and human genetic analysis to explore how variations in ROCK1 may contribute to obesity and related metabolic disorders. Patients may benefit from insights gained about the biological processes that regulate weight and energy levels.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals struggling with obesity or metabolic disorders, particularly those with a genetic predisposition to these conditions.
Not a fit: Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and related metabolic disorders by targeting specific signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding the melanocortin signaling pathway, indicating potential for significant advancements in obesity treatment.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Kim, Young-Bum — Beth Israel Deaconess Medical Center
- Study coordinator: Kim, Young-Bum
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.