Investigating how rhinoviruses affect airway function in asthma
Official title: Rhinovirus, airway smooth muscle, and mechanisms of irreversible airflow obstruction
Funded at Rutgers Biomedical and Health Sciences · NIH-11059989 · Data updated 2026-11-12
This study is looking at how common cold viruses called rhinoviruses can make asthma worse by affecting the cells in your airways, and it hopes to find new ways to help manage asthma better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 9, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $437,285 |
| NIH project number | 5R01HL166594-03 |
| Project ID | NIH-11059989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with asthma who experience frequent exacerbations triggered by respiratory infections.
✕Less likely to help
Patients with asthma who do not have rhinovirus-induced exacerbations or those with other underlying respiratory conditions may not benefit from this research.
What this research studies
This research explores the role of rhinoviruses in asthma exacerbations and how they influence the function of airway smooth muscle cells. By examining the cellular responses to rhinovirus exposure, the study aims to understand the mechanisms that lead to airway inflammation and obstruction. The researchers will utilize human airway tissue samples and various laboratory techniques to analyze changes in muscle cell behavior and signaling pathways. This could provide insights into potential therapeutic targets for improving asthma management.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve airway function and reduce asthma symptoms for patients.
How similar studies have gone: Previous research has shown that understanding viral impacts on airway function can lead to significant advancements in asthma treatment, indicating that this approach has potential for success.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Koziol-White, Cynthia — Rutgers Biomedical and Health Sciences
- Study coordinator: Koziol-White, Cynthia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.