Investigating how retrotransposons influence gene expression during early development
Retrotransposon derived promoters drive alternative host gene isoforms with important developmental functions
This study is looking at how certain genetic elements, called retrotransposons, help control gene activity during the early development of mammals, which could give us important clues about how development works and why some developmental disorders happen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11124612 on NIH RePORTER |
What this research studies
This research explores the role of retrotransposons, which are genetic elements that can change their position within the genome, in regulating gene expression during the early stages of mammalian development. By analyzing single-cell RNA sequencing data from various mammalian species, the researchers aim to understand how these retrotransposons act as alternative promoters for nearby genes, potentially leading to the production of different protein isoforms. This work could provide insights into the fundamental processes of development and gene regulation, which may have implications for understanding developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or developmental disorders that may be linked to gene regulation issues.
Not a fit: Patients with fully developed conditions unrelated to gene regulation or retrotransposon activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation during development, potentially leading to new strategies for addressing developmental disorders.
How similar studies have performed: Previous research has shown that retrotransposons can play significant roles in gene regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: He, Lin — University of California Berkeley
- Study coordinator: He, Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.