Investigating how retinoic acid influences brain development
The role of retinoic acid signaling in patterning the human cerebral cortex
This study is looking at how a form of vitamin A, called retinoic acid, helps shape important parts of the brain that affect thinking and memory, with the hope that it can lead to better treatments for conditions like autism.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11059871 on NIH RePORTER |
What this research studies
This research explores the role of retinoic acid, a derivative of vitamin A, in the development of the human cerebral cortex, particularly focusing on how it shapes different brain areas responsible for cognitive functions. Using a model derived from human stem cells, the study aims to understand the mechanisms by which retinoic acid contributes to the formation of specific brain regions, such as the lateral prefrontal cortex, which is crucial for decision-making and memory. The research is designed to uncover foundational insights that could lead to advancements in treating neurodevelopmental disorders like autism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those on the autism spectrum.
Not a fit: Patients with neurodevelopmental disorders not related to cortical development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders, improving cognitive outcomes for affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding brain development through similar approaches using stem cell models.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Cadwell, Cathryn Rene — University of California, San Francisco
- Study coordinator: Cadwell, Cathryn Rene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.