Investigating how retinoic acid affects cocaine craving and relapse
Retinoic acid, homeostatic plasticity and cocaine craving
This study is looking into why cravings for cocaine can get stronger even after someone has stopped using it for a while, and it's for anyone interested in understanding how certain brain proteins might help us find better ways to treat cocaine addiction and prevent relapses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10756140 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind cocaine addiction, particularly focusing on how cravings can intensify even after long periods of abstinence. Using a model that mimics human craving responses, the study examines the role of specific proteins in the brain that may influence the intensity of cravings. By understanding how these proteins interact with retinoic acid signaling, researchers aim to uncover potential targets for new treatments that could help manage cocaine addiction and prevent relapse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine use who have experienced cravings or relapse after periods of abstinence.
Not a fit: Patients who have never used cocaine or those with other substance use disorders unrelated to cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for reducing cocaine cravings and preventing relapse in individuals recovering from addiction.
How similar studies have performed: Previous research has shown promising results in understanding craving mechanisms in addiction, indicating that this approach may yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Wolf, Marina Elizabeth — Oregon Health & Science University
- Study coordinator: Wolf, Marina Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.