Investigating how removing a specific protein can protect the heart from damage.
Dissecting the Protective Role of Cardiac Hsp90ß Ablation/Inhibition
This study is looking at a protein called Hsp90β in heart cells to see how it helps protect the heart from damage, especially during problems like blocked blood flow, and it's designed to find new ways to help people with heart disease feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11104542 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called Hsp90β in heart function and its potential protective effects against heart damage caused by conditions like ischemia/reperfusion injury. The researchers have developed a special mouse model that allows them to study the effects of removing Hsp90β specifically from heart cells. By examining how this removal impacts heart health, they aim to uncover new therapeutic strategies that could improve outcomes for patients with heart diseases. The study will explore the mechanisms behind this protection and how it might lead to better treatments for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart diseases, particularly those at risk of ischemia/reperfusion injury.
Not a fit: Patients with non-cardiac conditions or those not experiencing heart dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart health and recovery from heart injuries.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for cardiac protection, suggesting potential for success in this approach.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Lam, Chi Keung — University of Delaware
- Study coordinator: Lam, Chi Keung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.