Investigating how reduced thioredoxin affects cancer development and aging in mice
Reduced thioredoxin in both the cytosol and mitochondria: a key modulator of age-related cancer development in Trx1KO x Trx2KO mice?
This study is looking at how a molecule called thioredoxin, which helps keep our cells healthy, affects cancer growth and aging by using special mice with lower levels of thioredoxin, and the results could help find new ways to prevent and treat cancer for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10884376 on NIH RePORTER |
What this research studies
This research explores the role of thioredoxin, a molecule that helps maintain a healthy cellular environment, in cancer development and aging. By studying genetically modified mice with reduced levels of thioredoxin in both the cytosol and mitochondria, researchers aim to understand how this reduction impacts tumor formation and lifespan. The approach involves observing the effects of thioredoxin down-regulation on oxidative stress and cancer progression, providing insights into potential mechanisms that could influence aging and cancer risk. Patients may benefit from findings that could lead to new strategies for cancer prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be older adults at risk for age-related cancers.
Not a fit: Patients with cancers unrelated to aging or those who are not elderly may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel approaches for reducing cancer risk and improving longevity in aging populations.
How similar studies have performed: Previous studies have shown that manipulating thioredoxin levels can influence cancer development, suggesting a promising avenue for further exploration.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Ikeno, Yuji — University of Texas Hlth Science Center
- Study coordinator: Ikeno, Yuji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.