Investigating how reduced hypusination affects heart function in heart failure patients.
Official title: Reduced hypusination of EIF5A impairs free ubiquitin generation resulting in the development of HFpEF
Funded at Johns Hopkins University · NIH-11114838 · Data updated 2026-11-12
This study is looking at how a specific factor in heart cells, called eIF5A, affects heart health in people with heart failure that has preserved ejection fraction (HFpEF), and it hopes to find new ways to help improve heart function for those living with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 15, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $126,387 |
| NIH project number | 1K99HL179380-01 |
| Project ID | NIH-11114838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Heart Failure with Preserved Ejection Fraction (HFpEF).
✕Less likely to help
Patients with heart failure types other than HFpEF may not receive benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind Heart Failure with Preserved Ejection Fraction (HFpEF), a condition affecting many heart failure patients. By analyzing heart tissue from HFpEF patients, the study examines the role of a specific translation factor, eIF5A, and its activation process called hypusination. The researchers will explore how reduced levels of eIF5A impact the production of proteins involved in cellular processes like ubiquitination, which is crucial for maintaining heart muscle health. The findings aim to uncover potential targets for new treatments that could improve heart function in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving heart function in patients with HFpEF.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein translation in heart failure, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Koleini, Navid — Johns Hopkins University
- Study coordinator: Koleini, Navid
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.