Investigating how redox stress affects pancreatic cancer driven by KRAS mutations
Official title: Defining Novel Redox Stress Mechanisms to Inhibit KRAS-driven Pancreatic Ductal Adenocarcinoma
Funded at University of Miami School of Medicine · NIH-10825261 · Data updated 2026-11-12
This study is looking at a tough type of pancreatic cancer to understand how certain molecules in the body can help or hurt tumor growth, with the hope of finding new treatment options that could make a difference for patients with this disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31CA288141-01 |
| Project ID | NIH-10825261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma, particularly those with KRAS mutations.
✕Less likely to help
Patients with other types of cancer or those without KRAS mutations may not benefit from this research.
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a highly lethal cancer primarily driven by mutations in the KRAS gene. The study aims to explore the role of reactive oxygen species (ROS) in tumor progression and how they can both promote and inhibit cancer growth. By examining the enzyme MTH1, which helps cancer cells manage oxidative stress, the research seeks to identify new therapeutic strategies that could target these vulnerabilities in KRAS-driven tumors. Patients may benefit from insights that could lead to more effective treatments for this aggressive cancer.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve survival rates for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promising results in targeting redox stress mechanisms in other cancer types, suggesting potential for success in this area.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Mateo-Victoriano, Beatriz — University of Miami School of Medicine
- Study coordinator: Mateo-Victoriano, Beatriz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.