Investigating how redox balance affects cyanide toxicity and mitochondrial diseases
The role of redox balance in cyanide toxicity and mitochondrial disease
This study is looking at how balancing certain chemicals in the body can help people who have been poisoned by cyanide or have mitochondrial diseases like Leigh syndrome, and it hopes to find ways to improve their health by fixing energy production in their cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10908691 on NIH RePORTER |
What this research studies
This research explores the role of redox balance in the context of cyanide poisoning and mitochondrial diseases like Leigh syndrome. It focuses on how disruptions in the electron transport chain lead to inefficient ATP production, particularly affecting the brain. The study aims to determine if normalizing the NAD+/NADH ratio can improve outcomes for patients suffering from cyanide toxicity and mitochondrial disorders. By understanding these mechanisms, the research seeks to identify potential therapeutic strategies for these serious conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by cyanide poisoning or those diagnosed with Leigh syndrome and other mitochondrial diseases.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction or cyanide exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cyanide poisoning and mitochondrial diseases, potentially saving lives and enhancing recovery.
How similar studies have performed: While the approach of normalizing NAD+/NADH ratios is promising, it is still largely untested in the context of cyanide toxicity and Leigh syndrome, making this research novel.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Tippetts, Emily — University of Utah
- Study coordinator: Tippetts, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.