Investigating how REDD1 affects insulin signaling in the heart
Official title: The role of REDD1 in insulin-mediated transcription
Funded at Virginia Polytechnic Inst and St Univ · NIH-11032026 · Data updated 2026-11-12
This study is looking at how a gene called REDD1 affects heart health in people with Type II diabetes, to help find better ways to improve insulin sensitivity and protect against heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $458,316 |
| NIH project number | 5R01HL168559-02 |
| Project ID | NIH-11032026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Type II diabetes who are at risk for cardiovascular diseases.
✕Less likely to help
Patients without Type II diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific gene, REDD1, in how insulin affects heart function, particularly in patients with Type II diabetes. The study aims to identify how REDD1 influences insulin sensitivity and resistance, which are critical factors in the development of diabetic cardiomyopathy, a condition that increases the risk of heart disease in diabetic patients. By using advanced genome-wide approaches, researchers will explore the mechanisms by which REDD1 operates in the heart, potentially leading to new treatment strategies that restore insulin sensitivity rather than just lowering blood sugar levels.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health in patients with Type II diabetes by enhancing insulin sensitivity.
How similar studies have gone: Previous research has shown promising results in understanding insulin signaling pathways, but the specific role of REDD1 in this context is still being explored.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Pfleger Karch, Jessica — Virginia Polytechnic Inst and St Univ
- Study coordinator: Pfleger Karch, Jessica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.