Investigating how red blood cells age and respond to oxidative stress
The role of ferroptosis in red cell aging in vivo and in vitro
This study looks at how red blood cells age and deal with stress in the body, focusing on the role of iron and certain proteins, to help improve our understanding of blood health and aging for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11036353 on NIH RePORTER |
What this research studies
This research explores the aging process of red blood cells (RBCs) and how they are affected by oxidative stress, which is a condition caused by an imbalance between free radicals and antioxidants in the body. The study examines the role of iron and specific proteins in RBCs that are crucial for their survival and function. By using both in vivo and in vitro models, researchers aim to understand how RBCs cope with damage over time and how this impacts overall health. The findings could lead to better management of conditions related to blood health and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing issues related to blood health or aging.
Not a fit: Patients with acute blood disorders or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve our understanding of blood cell aging and lead to new treatments for anemia and other blood-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding oxidative stress in red blood cells, indicating that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: D'alessandro, Angelo — University of Colorado Denver
- Study coordinator: D'alessandro, Angelo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.