Investigating how recombination rates vary and affect evolution
Recombination rate variation and evolution
['FUNDING_OTHER'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-11088914
This study is looking at how genes and the environment affect the way chromosomes mix during cell division, which is important for healthy reproduction and genetic variety, and it could help people understand fertility issues related to these processes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-11088914 on ClinicalTrials.gov |
What this research studies
This research explores the genetic and environmental factors that influence the rate of recombination during meiosis, which is crucial for proper chromosome segregation and genetic diversity. By using experimental evolution and genomics in yeast, the study aims to understand how recombination rates change over time and the implications of these changes on genome evolution. The research will involve whole genome sequencing to analyze recombination events and their conservation across different populations. Patients may benefit from insights into fertility issues related to meiotic failure and genetic diversity.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals experiencing fertility issues or those interested in genetic factors influencing reproductive health.
Not a fit: Patients who are not facing fertility challenges or have no interest in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors affecting fertility and population health.
How similar studies have performed: While the investigation of recombination rates is a well-established area, this specific approach using experimental evolution in yeast is relatively novel.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMUKOWSKI HEIL, CAITLIN SUZANNE — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: SMUKOWSKI HEIL, CAITLIN SUZANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.