Investigating how reactive astrocytes affect synapses in Alzheimer's disease
Reactive Astrogliosis and the Tripartite Synapse in Alzheimer's Disease
This study is looking at how certain brain cells, called reactive astrocytes, affect the health of connections between brain cells in people with Alzheimer's disease, to help find new ways to protect memory and thinking skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11052689 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of reactive astrocytes in Alzheimer's disease, particularly how they influence synaptic health. The study examines the balance between harmful and protective effects of these cells in the context of amyloid-beta and tau protein toxicity. By analyzing the upregulation of a specific protein called GFAP in reactive astrocytes, the research aims to clarify their contribution to synaptic loss and cognitive decline in Alzheimer's patients. This could lead to new insights into potential therapeutic targets for improving synaptic function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving cognitive function in Alzheimer's disease patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Serrano-Pozo, Alberto — Massachusetts General Hospital
- Study coordinator: Serrano-Pozo, Alberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.