Investigating how RAS signaling affects cell behavior
Chemical Genetic Analysis of RAS Signaling
This study is exploring how a protein called RAS helps control cell growth and survival, using a special tool to turn RAS on and off in a precise way, so we can better understand how it affects cells and their behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11035239 on NIH RePORTER |
What this research studies
This research focuses on understanding the RAS protein, which acts as a switch to control various cellular processes such as growth and survival. Using a novel tool called Chemically-Inducible Activator of RAS (CIAR), researchers can activate RAS signaling in a controlled manner to study its effects on cells. The study employs advanced techniques like phosphoproteomics and transcriptomics to analyze how RAS influences cellular dynamics and behavior. By examining localized RAS activation, the research aims to uncover the complexities of RAS signaling pathways and their feedback mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers driven by RAS mutations or dysregulation.
Not a fit: Patients with conditions unrelated to RAS signaling or those without cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer treatment by targeting RAS signaling pathways more effectively.
How similar studies have performed: Previous research has shown promising results in targeting RAS signaling, indicating potential for success with this novel approach.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Maly, Dustin J — University of Washington
- Study coordinator: Maly, Dustin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.