Investigating how Ras proteins switch their signaling roles during development
Understanding Ras effector switching and roles of Ras>RalGEF>Ral in development
This study is looking at a protein called Ras that plays an important role in how our bodies develop, especially in understanding some developmental disorders, and it hopes to uncover how Ras interacts with other signals to help explain certain birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10977059 on NIH RePORTER |
What this research studies
This research focuses on understanding the Ras protein, which is crucial in many developmental disorders. It aims to explore how Ras switches between different signaling pathways and the role of its downstream effector, RalGEF>Ral, in development. By using advanced techniques, the research will investigate the complex interactions of Ras with other signaling pathways and its implications for congenital abnormalities. The findings could provide insights into the biological processes that lead to developmental defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or developmental disorders associated with RASopathies.
Not a fit: Patients with conditions unrelated to Ras signaling or congenital defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital abnormalities linked to Ras signaling.
How similar studies have performed: While the specific approach of this research is novel, there have been successful studies exploring Ras signaling in other contexts.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Reiner, David — Texas A&m University Health Science Ctr
- Study coordinator: Reiner, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.