Investigating how rare genetic variants affect fat cell development and diabetes risk
In vivo and in vitro rare coding variant analyses to identify modulations of the adipocyte differentiation pathway that affect T2D risk
This study is looking at how certain genes might affect the way fat cells develop and how this could lead to Type 2 diabetes, with the hope that the findings could help create new treatments for people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10820459 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that influence the development of fat cells and their role in Type 2 diabetes (T2D). By analyzing rare genetic variants, the study aims to identify specific genes that may contribute to the risk of developing T2D through their effects on fat cell differentiation and lipid storage. The researchers will use both laboratory techniques and patient data to explore how these genetic factors can lead to insulin resistance and other metabolic issues associated with T2D. Patients may benefit from insights that could lead to new therapeutic strategies targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Type 2 diabetes or those who have been diagnosed with the condition.
Not a fit: Patients without any genetic predisposition to Type 2 diabetes or those with other forms of diabetes unrelated to adipocyte differentiation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for Type 2 diabetes that minimize complications.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors related to diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Flannick, Jason — Boston Children's Hospital
- Study coordinator: Flannick, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.