Investigating how Rap1 interacts with talin in blood cells
Direct Rap1-talin interaction in platelets, leukocytes, and endothelial cells
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10902039
This study is looking at how two proteins, Rap1 and talin, work together to help blood cells function properly, and it involves testing specially modified mice to see how changes in talin affect blood clotting and inflammation, which could help us understand blood-related health issues better.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10902039 on ClinicalTrials.gov |
What this research studies
This research explores the interaction between Rap1 and talin, two proteins that play crucial roles in the activation of integrins, which are important for blood cell function. The study will involve analyzing genetically modified mice to understand how changes in talin affect platelet structure and function, as well as their role in blood clotting and inflammation. By using advanced techniques, the researchers aim to uncover the mechanisms behind these interactions in platelets, leukocytes, and endothelial cells, which could lead to new insights into blood-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with bleeding disorders or conditions that affect blood clotting.
Not a fit: Patients with conditions unrelated to blood cell function or clotting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to blood clotting and inflammation.
How similar studies have performed: Other research has shown promising results in understanding protein interactions in blood cells, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GINSBERG, MARK HOWARD — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: GINSBERG, MARK HOWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.