Investigating how RAMS11 affects colorectal cancer progression and treatment resistance
The role of RAMS11 in colorectal cancer progression and treatment resistance
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10899507
This study is looking at a special RNA called RAMS11 to see how it affects colorectal cancer and why some treatments don’t work for everyone, with the hope of finding better ways to tailor treatments for patients based on their individual needs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10899507 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific RNA, RAMS11, in the progression of colorectal cancer (CRC) and its resistance to treatments. By analyzing tissue samples from patients with both primary and metastatic CRC, the study aims to identify molecular markers that can help stratify patients based on their risk and treatment needs. The approach includes advanced techniques like transcriptome sequencing and meta-analysis to uncover how RAMS11 influences cancer behavior and patient outcomes. Ultimately, the goal is to guide more personalized treatment decisions for patients with CRC.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with early-stage colorectal cancer who are at high risk for metastasis, as well as those with late-stage metastatic colorectal cancer.
Not a fit: Patients with non-colorectal cancers or those whose cancer is not amenable to the specific treatments being investigated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for colorectal cancer patients, improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using molecular markers to guide treatment decisions in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAHER, CHRISTOPHER A — WASHINGTON UNIVERSITY
- Study coordinator: MAHER, CHRISTOPHER A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.