Investigating how RABL6A and PP2A affect neuroendocrine tumors
Role of RABL6A-PP2A in neuroendocrine tumors
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11072006
This study is looking at how certain proteins affect the growth of pancreatic neuroendocrine tumors, with the hope of finding new treatments that could help patients with these tough-to-treat cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11072006 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms behind neuroendocrine tumors (NETs), which are challenging to treat and often incurable. The study explores the role of a specific pathway involving RABL6A and protein phosphatase 2A (PP2A) in the progression of pancreatic NETs. By examining how RABL6A promotes tumor growth and how PP2A acts as a tumor suppressor, the researchers aim to identify new therapeutic strategies. The use of small molecule activators of PP2A shows promise in reducing tumor cell proliferation and could lead to innovative treatments for patients with advanced NETs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced neuroendocrine tumors, particularly those with pancreatic NETs.
Not a fit: Patients with early-stage neuroendocrine tumors or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients with advanced neuroendocrine tumors.
How similar studies have performed: Other research has shown promise in targeting similar pathways in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUELLE, DAWN E — UNIVERSITY OF IOWA
- Study coordinator: QUELLE, DAWN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: advanced disease, anti-cancer, anti-cancer therapy, cancer metastasis