Investigating how R-loops affect DNA damage during antibody production in B cells
R-loop-induced DNA damage during immunoglobulin class switch recombination
This study is looking at how certain genetic processes in B cells, which are important for making antibodies, can be affected by special structures called R-loops, and it hopes to find ways to improve treatments for lymphoid cancers that might help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10673639 on NIH RePORTER |
What this research studies
This research focuses on understanding a genetic process called class switch recombination (CSR), where B cells change the type of antibodies they produce. The study examines how R-loops, which are structures formed during DNA and RNA interactions, influence DNA damage and repair during this process. By analyzing how these R-loops affect the repair of DNA breaks, the research aims to uncover mechanisms that could lead to better understanding of lymphoid cancers. Patients may benefit from insights that could improve treatments for conditions related to B cell function and malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to B cell function, such as certain blood cancers or immune disorders.
Not a fit: Patients with non-hematological conditions or those not related to B cell function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating certain types of blood cancers linked to B cell dysfunction.
How similar studies have performed: Other research has shown promising results in understanding DNA repair mechanisms in B cells, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Barlow, Jacqueline — University of California at Davis
- Study coordinator: Barlow, Jacqueline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.