Investigating how purinergic signaling affects Chagas disease
Targeting purinergic signaling in Chagas disease
This study is looking at how the immune system and inflammation affect Chagas disease, especially how certain molecules might influence heart problems in patients, with the goal of finding new ways to help improve treatment for those dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Research Council of Argentina NIH-funded |
| Lab location | 1 site (Cordoba, Argentina) |
| Project ID | NIH-11073080 on NIH RePORTER |
What this research studies
This research focuses on Chagas disease, which is caused by the Trypanosoma cruzi parasite and can lead to severe heart complications. The study aims to understand how the immune response and inflammation interact with the disease, particularly how ATP and its breakdown product, adenosine, influence the disease's progression. By examining these biological signals, the research seeks to identify potential new therapeutic targets that could improve treatment outcomes for patients suffering from Chagas cardiomyopathy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chagas disease, particularly those experiencing cardiac complications.
Not a fit: Patients who do not have Chagas disease or those with advanced heart failure unrelated to Chagas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Chagas disease, potentially reducing heart failure and other severe complications.
How similar studies have performed: While research on purinergic signaling is ongoing, this specific approach to Chagas disease is relatively novel and has not been extensively tested.
Where this research is happening
Cordoba, Argentina
- National Research Council of Argentina — Cordoba, Argentina (Active)
Researchers
- Principal investigator: Aoki, Maria Pilar — National Research Council of Argentina
- Study coordinator: Aoki, Maria Pilar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.