Investigating how purinergic receptors work and how they can be targeted for treatment
Structure/Function Studies on the Mechanisms of Purinergic Receptor Activation and Antagonism
This study is looking at special receptors in the heart that help it work properly, and it's trying to find new ways to block or activate these receptors to create better treatments for heart conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10438783 on NIH RePORTER |
What this research studies
This research focuses on purinergic (P2X) receptors, which are important for various bodily functions, particularly in the cardiovascular system. The study aims to understand how these receptors are activated and how they can be blocked by certain molecules, which could lead to new treatments for heart-related conditions. The researchers will use advanced techniques like ligand binding assays and electrophysiology to explore the structure and function of these receptors. By identifying new small molecules that can interact with these receptors, the research hopes to provide insights that could improve therapeutic options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from cardiovascular diseases, particularly those related to coronary artery conditions.
Not a fit: Patients with non-cardiovascular conditions or those not affected by purinergic receptor-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiovascular diseases by targeting purinergic receptors.
How similar studies have performed: Other research has shown promise in targeting purinergic receptors for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mansoor, Steven Elias — Oregon Health & Science University
- Study coordinator: Mansoor, Steven Elias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.