Investigating how pupil size affects brain processing related to attention and arousal
Noradrenergic and Cholinergic Mechanisms Underlying Pupil-linked Arousal Modulation of Thalamic Sensory Processing
This study is looking at how changes in pupil size, which relate to how alert and focused we are, affect how our brains process information, and it could help people with attention issues like ADHD understand their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893029 on NIH RePORTER |
What this research studies
This research explores how changes in pupil size, which are linked to arousal and attention, influence sensory processing in the brain. By examining the roles of noradrenergic and cholinergic systems, the study aims to understand how these mechanisms affect perception and behavior. The research utilizes advanced techniques, including CRISPR, to manipulate these systems and observe their effects on thalamic processing. Patients may benefit from insights into how attention-related disorders, such as ADHD, are influenced by these neural mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with attention deficit hyperactivity disorder (ADHD) or other related attention disorders.
Not a fit: Patients without attention-related disorders or those who do not exhibit atypical pupil dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for attention-related disorders by targeting specific brain mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between pupil dynamics and cognitive processes, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Wang, Qi — Columbia Univ New York Morningside
- Study coordinator: Wang, Qi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.