Investigating how psychedelics affect brain function and adaptability
Official title: Effects of Psychedelics on Brain Function and Neuroplasticity
Funded at Washington University · NIH-11001408 · Data updated 2026-11-12
This study is looking at how psilocybin, a psychedelic substance, affects the brain in people aged 21 and older, with the hope of finding new ways to help those who struggle with mental health issues when other treatments haven't worked.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $43,574 |
| NIH project number | 1F99NS139512-01 |
| Project ID | NIH-11001408 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing treatment-resistant psychiatric disorders.
✕Less likely to help
Patients under 21 years old or those without psychiatric disorders may not benefit from this research.
What this research studies
This research explores the effects of psychedelics, specifically psilocybin, on brain function and neuroplasticity in individuals aged 21 and older. It aims to understand how these substances interact with serotonin receptors and influence neuronal activity and blood flow in the brain. By using advanced imaging techniques like functional magnetic resonance imaging (fMRI), the study seeks to accurately map changes in brain activity and structure that may help treat psychiatric disorders. The findings could provide insights into new therapeutic approaches for individuals who are resistant to traditional psychiatric medications.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for psychiatric disorders, offering hope to patients who have not responded to conventional therapies.
How similar studies have gone: Previous research has shown promising results with psychedelics in treating mood and substance use disorders, indicating a potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Padawer-Curry, Jonah — Washington University
- Study coordinator: Padawer-Curry, Jonah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.