Investigating how PRSS1 mutations lead to pancreatic cancer
PRSS1 Mutation and Pancreatic Cancer Tumorigenesis
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-10918185
This study is looking at how changes in a specific gene can lead to pancreatic cancer in people with a family history of pancreatitis, using a special mouse model to find out what happens early on that might cause cancer, which could help create better ways to prevent and treat the disease for those at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10918185 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms by which mutations in the PRSS1 gene contribute to the development of pancreatic cancer, particularly in patients with hereditary pancreatitis. By using a novel mouse model that mimics the human condition, researchers aim to identify the early events that trigger the progression from pancreatitis to cancer. The study seeks to uncover critical signaling pathways involved in tumorigenesis, which could lead to the development of targeted preventive and therapeutic strategies for at-risk individuals. Patients with hereditary pancreatitis may find this research particularly relevant as it addresses their specific genetic risk factors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hereditary pancreatitis or those carrying PRSS1 mutations.
Not a fit: Patients without a genetic predisposition to pancreatic cancer or those not affected by hereditary pancreatitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures and treatments for pancreatic cancer in patients with hereditary pancreatitis.
How similar studies have performed: Previous research has shown promise in understanding pancreatic cancer mechanisms through genetic studies, but this specific approach using a novel animal model is relatively new.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JI, BAOAN — MAYO CLINIC JACKSONVILLE
- Study coordinator: JI, BAOAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause