Investigating how proton signaling affects nerve communication in ALS
Official title: The Role of Proton-Mediated Signaling at the Neuromuscular Junction in ALS Models
Funded at University of Nevada Reno · NIH-11120770 · Data updated 2026-11-12
This study is looking at how changes in acidity in the body might affect the way nerves and muscles communicate in people with ALS, with the hope of finding new ways to help improve movement and overall health for those living with the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | June 3, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $387,525 |
| NIH project number | 1R21NS142775-01 |
| Project ID | NIH-11120770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis (ALS) or those at risk of developing the condition.
✕Less likely to help
Patients with other neurological disorders unrelated to ALS may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of proton-mediated signaling at the neuromuscular junction in models of amyotrophic lateral sclerosis (ALS). It aims to explore how changes in pH levels, which are characteristic of ALS, affect communication between nerves and muscles. By studying these mechanisms, the research seeks to identify potential therapeutic targets that could improve motor function and survival in ALS. The approach involves examining the effects of extracellular protons on ion movement at the neuromuscular junction, particularly in the context of ALS pathology.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve motor function and extend survival for patients with ALS.
How similar studies have gone: Previous research has shown promising results in ALS models using similar approaches, indicating potential for success in this area.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Renden, Robert B — University of Nevada Reno
- Study coordinator: Renden, Robert B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.