Investigating how proteins on catheters contribute to urinary tract infections.
Understanding the role of catheter-associated protein deposition in the development of CAUTI
This study is looking at how certain proteins and bacteria that build up on urinary catheters can cause infections, especially in older adults who often use these catheters, with the hope of finding better ways to prevent and treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-11041053 on NIH RePORTER |
What this research studies
This research focuses on understanding how proteins that accumulate on urinary catheters can lead to catheter-associated urinary tract infections (CAUTI). By examining the unique pathogens that thrive in the presence of catheters, the study aims to uncover the mechanisms behind these infections, which are a significant concern in healthcare settings. The research will involve analyzing bladder inflammation and the specific bacteria involved in CAUTI, particularly in the context of an aging population that increasingly relies on catheters. The ultimate goal is to develop strategies to prevent and treat these infections effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who require urinary catheters, particularly older adults or those with chronic health conditions.
Not a fit: Patients who do not use urinary catheters or have no history of urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for urinary tract infections related to catheter use, enhancing patient safety and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of CAUTI, but this specific approach to studying protein deposition on catheters is relatively novel.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Flores-Mireles, Ana Lidia — University of Notre Dame
- Study coordinator: Flores-Mireles, Ana Lidia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.