Investigating how proteins interact with RNA in cancer
Protein-RNA interactions in cancer
This study is looking at how a protein called IGF2BP3 interacts with RNA in cancer, especially in aggressive leukemia, to help us understand how these interactions might affect treatment and progression of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10895345 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between RNA-binding proteins and RNA molecules, particularly in the context of cancer. It explores how the protein IGF2BP3 influences the stability and splicing of mRNA, which are crucial processes in gene regulation. By using advanced genetic models, the research aims to uncover the role of IGF2BP3 in the development of aggressive forms of leukemia. Patients may benefit from insights gained about how these interactions contribute to cancer progression and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute leukemia or those at risk for aggressive cancer types.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with acute leukemia may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting RNA-protein interactions in cancer.
How similar studies have performed: Previous research has shown promising results in targeting RNA-binding proteins for cancer treatment, indicating potential for success in this area.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Sanford, Jeremy Robert — University of California Santa Cruz
- Study coordinator: Sanford, Jeremy Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.